In Genesis 6, we read of a strange and disturbing time when “the sons of God came in to the daughters of men, and they bore children to them” (Genesis 6:4). These children were the Nephilim, mysterious hybrid beings who were “mighty men… men of renown.” While scholars debate the exact identity of the “sons of God,” my view is that they were fallen angels who transgressed their boundaries, resulting in a corrupted human race.
Jesus offered a chilling comparison in Matthew 24:37: “For the coming of the Son of Man will be just like the days of Noah.” This comparison begs a sobering question: If the world before the flood was marked by genetic corruption and hybrid entities, could we be heading toward a similar scenario today?
With CRISPR-Cas9, synthetic biology, and other advanced genetic engineering technologies at our fingertips, we are now able to manipulate DNA in ways unimaginable just decades ago. While these breakthroughs offer promising medical benefits, they also raise profound moral and theological concerns—especially when viewed through a prophetic lens.
The Days of Noah: A Time of Genetic Corruption
Genesis 6 describes not only extreme violence and wickedness, but also a profound corruption of human flesh:
“Then the LORD saw that the wickedness of man was great on the earth… and God looked on the earth, and behold, it was corrupt; for humanity had corrupted its way upon the earth” (Genesis 6:5, 12).
The Book of Enoch—though not canonical—shed more light on this corruption, describing how fallen angels taught humans forbidden knowledge, including weaponry, enchantments, astrology, and the manipulation of genetics. According to Enoch 7:2, the offspring of these unions were giants who “consumed all the acquisitions of men,” unleashing destruction upon the earth.
The flood wasn’t just about cleansing moral wickedness. It was also about preserving the integrity of God’s creation, especially the human genome. Noah is described as “blameless in his generations” (Genesis 6:9)—a phrase many believe refers to his uncontaminated lineage, not merely his moral character.
Jesus’ Warning: A Prophetic Parallel
When Jesus likens the Last Days to the “days of Noah,” He isn’t merely pointing to general wickedness or moral decay—though those are certainly present. He is referencing a time of spiritual and genetic rebellion, when boundaries between human and non-human were blurred.
Consider what we see today:
- Genetically modified embryos are being created and destroyed in laboratories.
- Human-animal chimeras are being developed for organ harvesting.
- Gene-editing technologies are being used to “enhance” human traits—raising the specter of designer babies, super soldiers, and possibly even post-human entities.
These developments raise a critical question: Are we opening a door once sealed by God after the flood? If the Nephilim were a product of angelic-human hybridization in Genesis 6, then our modern scientific pursuits may be ushering in a return of those hybrid beings—not through supernatural union but through technological sorcery.
CRISPR and the Modern Tower of Babel
CRISPR-Cas9 is a gene-editing tool that allows scientists to cut and paste sections of DNA with extreme precision. While originally hailed as a cure for genetic diseases, CRISPR has quickly expanded into areas of genetic enhancement and embryonic modification. In 2018, Chinese scientist He Jiankui shocked the world by announcing the birth of the first CRISPR-edited babies, sparking an international outcry.
The Tower of Babel (Genesis 11) represents another moment when humanity attempted to transcend God-ordained boundaries. They sought to “make a name for ourselves” and reach the heavens through their own ingenuity. God responded by scattering them and confusing their languages. Today, mankind is once again reaching for godlike powers—this time not through bricks and towers but through genes and machines.
“There is nothing that they purpose to do that will be impossible for them” (Genesis 11:6b).
This verse takes on new meaning in the age of synthetic biology, where scientists talk openly about “playing God” and “creating life” in the lab. Like the men of Babel, we are seeking immortality and dominion without the Creator.
Hybrid Beings and Transhumanism: Echoes of the Nephilim?
The Nephilim were hybrids—part divine, part human. Today’s scientists envision a future of transhumans: beings who are part human, part machine, or genetically enhanced beyond what God intended. The transhumanist movement openly advocates for the next step in evolution—a post-human future where our biology is no longer a limitation but a canvas for re-creation.
Even secular voices are alarmed. Elon Musk has warned of the dangers of AI-human symbiosis, and Yuval Noah Harari has famously described humans as “hackable animals.” In his worldview, free will is an illusion, and the future belongs to those who control the genome and the algorithm.
Could it be that we are re-creating the very conditions that led to the flood? Could hybrid beings return, not through angelic rebellion but through technological apostasy?
The Spiritual War Behind the Science
Ephesians 6 reminds us that “we wrestle not against flesh and blood, but against principalities, against powers… against spiritual forces of wickedness in heavenly places” (Ephesians 6:12). Just as the Nephilim were not merely genetic anomalies, today’s bioengineering feats are not neutral; they are spiritually charged.
Satan has always sought to corrupt the image of God. In the garden, he tempted Eve with the promise that she could “be like God” (Genesis 3:5). In Genesis 6, he attempted to destroy the Messianic bloodline through hybridization. Now, in the modern age, he is inspiring a new generation of scientists to remake humanity in a counterfeit image.
Even mainstream bioethicists warn that humanity is venturing into dangerous territory. Once we cross the line of germline editing (modifying DNA in ways that pass on to future generations), we are engaging in permanent alterations of the human species.
This is not simply technological innovation—it is rebellion, a new form of genetic idolatry.
The Prophetic Implications
The book of Daniel says that in the Last Days, “knowledge will increase” (Daniel 12:4). Revelation describes a Beast system marked by global control, advanced image-making, and a mark that changes humanity’s destiny (Revelation 13:16-17).
Could the mark of the beast involve genetic manipulation? Some prophecy teachers speculate that it may include biometric or genetic encoding—something that alters not just one’s ability to buy or sell but one’s very identity. If the Nephilim were irredeemable because they were no longer fully human, then it is possible that those who take the mark in the future could be permanently altered, disqualifying themselves from salvation (Revelation 14:9-11).
This fits with Satan’s strategy: to corrupt the image of God, replacing it with something hybridized, digitized, or mechanized. As in the days of Noah, humanity is being lured into a grand deception. A future where salvation is redefined and humanity is reengineered.
Redeeming the Narrative: A Call to Watch and Warn
Yet, we are not without hope. Jesus said, “When you see these things begin to happen, look up and lift up your heads, because your redemption is drawing near” (Luke 21:28). The rise of genetic manipulation is not only a sign of human arrogance—it is also a sign of prophetic acceleration. It tells us that the return of Christ is near.
As watchmen, we must sound the alarm. We must warn others that science without God becomes sorcery, that human enhancement without divine boundaries becomes rebellion, and that technology divorced from truth leads to deception.
We are called to resist the Nephilim spirit of this age—whether it comes in the form of fallen angels, genetic hybrids, or AI entities mimicking life. As Paul warned in 2 Thessalonians 2, a great deception is coming, one that will include lying signs and wonders. Our safeguard is the truth of God’s Word, our hope is in the return of Christ, and our strength is in the Holy Spirit.
Conclusion: Standing Firm in a Hybrid Age
The world is being prepared for a return to the days of Noah—where boundaries are erased, flesh is corrupted, and mankind is seduced by forbidden knowledge. We are not simply witnessing a scientific revolution. We are witnessing a spiritual reformation of evil.
The Nephilim of Genesis 6 were a warning. The words of Jesus in Matthew 24 are a reminder. And the prophecies of Revelation are a roadmap for what’s coming.
Let us watch. Let us warn. Let us hold fast to the truth in these final moments before the ark door closes again.
“As it was in the days of Noah, so it will be at the coming of the Son of Man” (Matthew 24:37).
Stay Awake! Keep Watch!